产品说明
免疫原
Mimitin antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Mimitin.
特点和优势
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目标描述
Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kB-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.
联系
The action of this antibody can be blocked using blocking peptide SBP3500112.
外形
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
基本信息
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
偶联物 | unconjugated |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | buffered aqueous solution |
species reactivity | human |
technique(s) | immunofluorescence: suitable indirect ELISA: suitable western blot: suitable |
NCBI登记号 | NP_777549 |
UniProt登记号 | Q8N183 |
运输 | dry ice |
储存温度 | −20℃ |
Gene Information | human ... NDUFAF2(91942) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |