产品说明
一般描述
Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that exists in bi-lobal conformation. Structurally, MELK comprises an N-terminal catalytic domain, ubiquitin-associated (UBA) domain, and a kinase domain. The MELK gene is mapped to human chromosome location 9p13.2.The MELK antibody detects endogenous levels of total MELK protein.
免疫原
Peptide sequence around aa. 626-630 (I-R-R-Q-R), according to the protein NP_055606.1
应用
Anti-MELK antibody produced in rabbit has been used in western blotting at a dilution of 1:1000.
生化/生理作用
Maternal embryonic leucine zipper kinase (MELK) participates in cell cycle regulation by interacting with cell cycle proteins. It may have a role in malignant cell survival and cancer stem cell growth. An elevated expression of MELK is observed in triple-negative breast cancer, glioblastoma multiforme(GBM), and astrocytomas.
特点和优势
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目标描述
Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~74 kDa |
| species reactivity | human, rat, mouse |
| 浓度 | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (I-R-R-Q-R) |
| NCBI登记号 | NM_014791.2 |
| UniProt登记号 | Q14680 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MELK(9833) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
