产品说明
一般描述
MECR (Mitochondrial trans-2-enoyl-CoA reductase) is a mitochondrial localized protein, also referred to as nuclear receptor binding factor-1 (NRBF-1). It consists of N-terminal mitochondrial targeting sequence, which plays an essential role for its mitochondrial localization. It was firstly identified as a binding protein of the nuclear hormone receptor peroxisome proliferator-activated receptor (PPARα).
免疫原
MECR (NP_057095.2, 1 a.a. ~ 373 a.a) full-length human protein.
Sequence
MWVCSTLWRVRTPARQWRGLLPASGCHGPAASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM
生化/生理作用
MECR (Mitochondrial trans-2-enoyl-CoA reductase) plays a vital role in the intracellular signaling pathways of fatty acid elongation cycle pathway. In the nuclei, it catalyzes reduction reaction of trans-2-enoyl thioesters to the corresponding saturated acyl thioesters in the presence of NADPH. It has also been reported that MECR acts as a component of the mitochondrial FAS II (fatty acid synthesis II) pathway and enhances the PPARa-dependent luciferase activity in HeLa cells.
外形
Solution in phosphate buffered saline, pH 7.4
基本信息
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
偶联物 | unconjugated |
抗体形式 | purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | buffered aqueous solution |
分子量 | antigen 40.5 kDa |
species reactivity | human |
technique(s) | western blot: 1 μg/mL |
NCBI登记号 | NM_016011.2 |
UniProt登记号 | Q9BV79 |
运输 | dry ice |
储存温度 | −20℃ |
Gene Information | human ... MECR(51102) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |