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Anti-MBNL2 Antibody, clone MB2a(3B4)

品牌
Sigma-Aldrich
货号
MABE959
规格纯度
clone MB2a(3B4), 1 mg/mL, from mouse
参考价格
4438.28 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

MBNL2, also known as Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, or Muscleblind-like protein-like 39, and encoded by the gene MBNL2/MBLL/MBLL39/MLP1, is a protein that mediates pre-mRNA alternative splicing regulation. MBNL2 acts either as an activator or repressor of splicing on specific pre-mRNA targets. For instance MBNL2 inhibits cardiac troponin-T pre-mRNA exon inclusion but induces insulin receptor pre-mRNA exon inclusion in muscle. MBNL2 may also regulate ITGA3 expression by transporting it from the nucleus to cytoplasm at adhesion plaques. MBNL2 appears to play a key role in the muscle disease named myotonic dystrophy pathophysiology. MBNL2 is expressed in the nucleus of cells in multiple tissues but can be found in the cytoplasm in certain situations. In particular it is found in the cytoplasm in adhesion plaques.

免疫原

Recombinant protein corresponding to human MBNL2.

应用

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Nuclear Receptors
This Anti-MBNL2 Antibody, clone MB2a(3B4) is validated for use in Western Blotting for the detection of MBNL2.

质量

Evaluated by Western Blotting in C2C12 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected MBNL2 in 10 µg of C2C12 cell lysate.

目标描述

~40 kDa observed

外形

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified
Format: Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆MB2a(3B4), monoclonal
species reactivitymouse
species reactivity (predicted by homology)human (based on 100% sequence homology)
浓度1 mg/mL
technique(s)western blot: suitable
同位素/亚型IgG2bκ
NCBI登记号NP_659002
UniProt登记号Q5VZF2
运输wet ice
Gene Informationhuman ... MBNL2(10150)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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