Anti-mA20 Antibody/TNFAIP3, clone 37

产品说明

一般描述

TNFAIP3/mA20, also known as Tumor necrosis factor alpha-induced protein 3, OTU domain-containing protein 7C, Putative DNA-binding protein A20, or Zinc finger protein A20, and encoded by the gene TNFAIP3/OTUD7C, is an ubiquitin editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. TNFAIP3/mA20 is involved in immune and inflammatory responses signaled by cytokines or pathogens through the Toll-like receptors and ultimately regulating NF-kappa-B activity. TNFAIP3/mA20 is an essential component of the ubiquitin editing protein complex consisting of RNF11, ICTH, and TAX1BP1 and ensures the transient nature of inflammatory signaling. TNFAIP3/mA20 is also a key player in switching of Lys-63 polyubiquitinated chains to Lys-48 polyubiquitinated chains for the subsequent degradation of specific targets as well. TNFAIP3/mA20 is located in the cytoplasm but can be found in the nucleus and lysosome depending upon the microenvironment and stimulus.

免疫原

Recombinant protein corresponding to Mouse mA20/TNFAIP3.

应用

Research Sub Category
Apoptosis - Additional
Detect mA20/TNFAIP3 using this Anti-mA20 Antibody/TNFAIP3, clone 37 validated for use in flow cytometry.
Research Category
Inflammation & Immunology

质量

Evaluated by Flow Cytometry in mouse splenocytes.

Flow Cytometry Analysis: 2 µg of this antibody detected mA20/TNFAIP3 in 1X10E6 mouse splenocytes.

This antibody was produced in collaboration with the Scripps Research Institute.For Scripps Research Institute Validation (Click Here)

目标描述

90 kDa calculated

外形

Purified by Ion-Exchange Chromatography
Purified rat monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Format: Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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