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Anti-LRP1 (C-term) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1300081
规格纯度
IgG fraction of antiserum, buffered aqueous solution
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

LRP1 (low density receptor protein 1) gene codes for a protein belonging to LDL receptor family. Lrp1 is known to be the largest mammalian endocytic receptor. The encoded protein is cysteine-rich and it is highly glycosylated. It is predominantly expressed in vascular smooth muscle cells, neurons, astrocytes, macrophages, hepatocytes, fibroblasts and malignant cells. The LDLRs (low-density lipoprotein receptors) have five domains namely repeated cysteine-rich regions of ligand-binding type and epidermal growth factor receptor-like repeats, YWTD (tyrosin, typrtophan, Threonine, aspartic) domains, a transmembrane domain, and a cytoplasmic tail that holds about three NPXY (asparagine-proline-X-tyrosine) motifs.

免疫原

LRP1 (4520-4554)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP1.

生化/生理作用

LRP1 functions as a scavenger by internalizing several plasma components and also serves as a signaling molecule. Lrp1 is responsible for the transport of β-amyloid (Aβ) across the blood brain barrier, thereby contributing to the pathogenesis of Alzheimer′s disease. Lrp1 is normally associated with the cell membrane, but proteolytic cleavage of the cell results in its soluble form. Therefore, it loses its ability to endocytose and transport ligands. LRP1 is associated with a number of signaling pathways, such as mitogen-activated protein kinase (MAPK), serine/threonine protein kinase (AKT), insulin receptor (IR), extracellular signal-regulated kinase (ERK), and c-jun N-terminal kinase (JNK) pathways.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
NCBI登记号NP_002323
UniProt登记号Q07954
运输dry ice
储存温度−20℃
Gene Informationhuman ... LRP1(4035)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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