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Anti-LAG3 Antibody, clone 8C7.1

品牌
Sigma-Aldrich
货号
MABF294
规格纯度
culture supernatant, clone 8C7.1, from mouse
参考价格
4681.07 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Lymphocyte activation gene 3 protein (UniProt P18627; also known as CD223, LAG-3, Protein FDC) is encoded by the LAG3 (also known as FDC) gene (Gene ID 3902) in human. LAG3 is a single-pass type I membrane protein that binds MHC class II molecules on antigen presenting cells with high affinity. LAG3 expression is induced after T cell activation and functions as a negative regulator of T cell function. LAG3 blockage is shown to augment T cell proliferation and cytokine production, and LAG3-deficient mice have a defect in the downregulation of T cell responses induced by staphylococcal enterotoxin B or by virus infection. In addition, LAG3 is expressed on activated regulatory T (Treg) cells at higher levels than on activated effector T cells. LAG3 blockage inhibits the suppressive activity of Treg cells. LAG3 is also upregulated on tumour-infiltrating lymphocytes (TILs), and LAG3 blockage can enhance anti-tumour T cell responses.

免疫原

Mouse Fc-tagged recombinant human LAG3 extracellular fragment.

应用

This Anti-LAG3 Antibody, clone 8C7.1 is validated for use in Western Blotting, Flow Cytometry for the detection of LAG3.
Flow Cytometry Analysis: A 1:100 dilution of this antibody from a representative lot detected LAG3 in 1X10E6 Jurkat cells subjected to CD3/CD28 costimulation.

质量

Evaluated by Western Blotting in NK-92c ell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected LAG3 in 10 µg of NK-92 cell lysate.

目标描述

~60 kDa observed

外形

Unpurified
Mouse monoclonal IgG2aκ antibody tissue culture supernatant with 0.05% sodium azide.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式culture supernatant
antibody product typeprimary antibodies
克隆8C7.1, monoclonal
species reactivityhuman
technique(s)flow cytometry: suitable
western blot: suitable
同位素/亚型IgG2aκ
NCBI登记号NP_002277
UniProt登记号P18627
运输dry ice
Gene Informationhuman ... LAG3(3902)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1

Sigma-Aldrich

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