产品说明
一般描述
Kindlin-1 is coded by FERMT1 (fermitin family member 1) gene. It is a focal adhesion protein, expressed in the skin and intestine. FERMT1 is located on human chromosome 20p.12.3.
免疫原
synthetic peptide corresponding to a sequence close to the N-terminus of human Kindlin-1, conjugated to KLH. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Monoclonal Anti-Kindlin-1 antibody has been used in immunohistochemistry, immunofluorescence staining and western blotting.
生化/生理作用
Kindlin-1 protein, coded by FERMT1 gene modulates keratinocyte electrotaxis. It participates in the initiation of the integrin family of extracellular matrix receptors. FERMT1 maintains the lamellipodial protrusions at the time of electrotaxis. Mutations in kindlin-1 results in Kindler syndrome (KS).
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| 克隆 | KN-4, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~50 kDa (isoform 4) antigen ~60 kDa (isoform 2) antigen ~77 kDa (isoform 1) |
| species reactivity | mouse, human |
| 浓度 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: 2.5-5.0 μg/mL using SW-620 cells western blot: 1.0-2.0 μg/mL using SW-48 total cell extracts |
| 同位素/亚型 | IgG1 |
| UniProt登记号 | Q9BQL6 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... FERMT1(55612) mouse ... Fermt1(241639) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
