产品说明
一般描述
Keratin 17 plays a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. It may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells" and also act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. It is required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state and modulates the function of TNF-alpha in the specific context of hair cycling. It regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway and is involved in tissue repair. Keratin 17 is expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. It is also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
免疫原
Synthetic peptide corresponding to C-terminus of human keratin 17 protein.
特点和优势
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外形
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 重组 | expressed in proprietary host |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | SP95, monoclonal |
| species reactivity | human (tested) |
| species reactivity (predicted by homology) | bovine, mouse, dog, rat |
| technique(s) | flow cytometry: 1:100 immunoblotting: 1:25 immunohistochemistry: 1:100 |
| 同位素/亚型 | IgG |
| UniProt登记号 | Q04695 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | human ... KRT17(3872) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
