Anti-JPH3 Antibody

产品说明

一般描述

Junctophilin-3 (JPH3, JP-3), also known as Trinucleotide repeat-containing gene 22 protein (TNRC22), is a single-pass type IV membrane protein belonging to the junctophilin family. Junctophilins are important components of the junctional complexes which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. JPH3 is specifically expressed in brain. A mutation associated with JPH3 is the cause of Huntington disease-like type 2 (HDL2), a neurodegenerative disorder.

特异性

This antibody recognizes the C-terminus of JPH3.

免疫原

KLH-conjugated linear peptide corresponding to a sequence near the C-terminus of human JPH3.
Epitope: Near C-terminus.

应用

Anti-JPH3 Antibody is a highly specific rabbit polyclonal antibody, that targets Junctophilin-3 & has been tested in western blotting, IHC & Immunofluorescence.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected JPH3 in human brain tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected JPH3 in human brain cells.

质量

Evaluated by Western Blotting/Peptide Inhibition Assay in Daudi cell lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected JPH3 in 15 µg of Daudi cell lysate.

目标描述

~105 kDa observed. Uniprot describes 2 isoforms at ~20 kDa and ~81 kDa Uncharacterized bands may appear in some lysates.

外形

Purified rabbit polyclonal antibody in buffer containing PBS with 0.02% sodium azide.
Affinity purified.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Daudi cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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