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Anti-JARID1C Antibody

品牌
Sigma-Aldrich
货号
ABE1082
包装型号
规格纯度
from rabbit
参考价格
5206.52 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

JARID1C, also known as Jumonji/ARID domain-containing protein 1C, Protein SmcX, or Protein Xe169, and encoded by the gene KDM5C/DXS1272E/JARID1/SMCX/XE169, a histone demethylase that specifically demethylates ′Lys-4′ of histone H3, thereby playing a central role in histone code. JARID1C demethylates trimethylated and dimethylated but not monomethylated H3 ′Lys-4′. JARID1C does not demethylate histone H3 ′Lys-9′, H3 ′Lys-27′, H3 ′Lys-36′, H3 ′Lys-79′ or H4 ′Lys-20′. Additionally, JARID1C participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. JARID1C is localized to the nucleus. Defects in JARID1C are associated with Mental retardation, X-linked, syndromic, Claes-Jensen type (MRXSCJ) disorder. MRXSCJ patients have below average general intellectual functioning associated with impairments in adaptive behavior during development, and suffer mental retardation, progressive spastic paraplegia, seizures, and facial dysmorphism.

免疫原

Linear peptide corresponding to human JARID1C.

应用

Anti-JARID1C Antibody detects level of JARID1C & has been published & validated for use in JARID1C.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology

质量

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected JARID1C in 10 µg of HEK293 cell lysate.

目标描述

~175 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein A purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式purified antibody
antibody product typeprimary antibodies
克隆polyclonal
species reactivityhuman
technique(s)western blot: suitable
NCBI登记号NP_001140174
UniProt登记号P41229
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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