产品说明
一般描述
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
免疫原
A synthesized peptInsulin-degrading enzyme (Insulin-degrading enzyme (IDE)) derived from human Insulin-degrading enzyme (Insulin-degrading enzyme (IDE))
外形
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| antibody product type | primary antibodies |
| 克隆 | monoclonal |
| 形式 | liquid |
| species reactivity | mouse, rat, human |
| 浓度 | 0.5 mg/mL |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt登记号 | P14735 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... IDE(3416) |
安全信息
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
