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Anti-IGF2BP2 Antibody, clone 5E10-3E1

品牌
Sigma-Aldrich
货号
MABE232
规格纯度
clone 5E10-3E1, from mouse
参考价格
5352.52 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is a member of the IGF-II mRNA binding protein family that posttranscriptionally regulates IGF2 during developmental stages. IGF2 mRNA-binding protein family members (IGF2BP1, 2 and 3) bind UTR region of IGF2 transcripts and are implicated in the transport of RNA targets to enable protein synthesis at specific locations in the cytoplasm. Studies have indicated variations in the IGF2BP2 gene may affect fetal glucose metabolism and plays a role in type 2 diabetes. In addition to playing a role in glucose metabolism and dieabetes, the insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. Research has shown IGF2 to be emerging as an important gene for ovarian cancer.

免疫原

Histidine-tagged recombinant protein corresponding to human IGF2BP2.

应用

Research Category
Epigenetics & Nuclear Function
Research Sub Category
RNA Metabolism & Binding Proteins
Use Anti-IGF2BP2 Antibody, clone 5E10-3E1 (mouse monoclonal antibody) validated in WB to detect IGF2BP2 also known as Insulin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, IMP-2, Hepatocellular carcinoma autoantigen p62.

质量

Evaluated by Western Blot in HepG2 cell lysate.

Western Blot Analysis: A 1:20,000 dilution of this antibody detected IGF2BP2 on 10 µg of HepG2 cell lysate.

目标描述

~66 kDa observed. An uncharacterized band at ~50 kDa may be observed in some lysates. Alternative splicing can result in 5 isoforms with molecular weights ranging from 55-66 kDa

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
HepG2 cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆5E10-3E1, monoclonal
species reactivityhuman
technique(s)western blot: suitable
同位素/亚型IgG1κ
NCBI登记号NP_001007226
UniProt登记号Q9Y6M1
运输wet ice
Gene Informationhuman ... IGF2BP2(10644)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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