产品说明
一般描述
mgbp-2/hGBP-1, or also known as Interferon-induced guanylate-binding protein 1, GTP-binding protein 1 (GBP-1/HuGBP-1), or Guanine nucleotide-binding protein 1, and encoded by the gene GBP1, is another enzyme important in innate defense. Among its functions, this enzyme hydrolyzes GTP to GMP and appears to promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, thus providing broad host protection against different pathogen classes. mgbp-2/hGBP-1 is localized to the cytoplasm but is also secreted in endothelial cells and localizes to the cytoplasmic side of the Golgi apparatus in expressing most cells. Interestingly, mgbp-2/hGBP-1is secreted by the endothelial cells in the CNS upon bacterial challenge even when not induced by gamma interferon. The enzyme is also induced by TNF-alpha and IL-1beta expression by immune cells and is considered a proinflammatory response factor.
免疫原
GST-tagged recombinant protein corresponding to hu GBP-1/GBP-1.
应用
Research Category
Cell Structure
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected hu GBP-1/GBP-1 in human spleen tissues and rat brain tissue.
This Anti-Hu GBP-1/GBP-1 Antibody, clone 6C5.1 is validated for use in western blotting & IHC (Paraffin) for the detection of Hu GBP-1/GBP-1.
Research Sub Category
ECM Proteins
质量
Evaluated by Western Blotting in human spleen tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected hu GBP-1/GBP-1 in 400 µg of human spleen tissue lysate.
目标描述
~68 kDa observed
外形
Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
质量水平 | 100 |
生物来源 | mouse |
抗体形式 | purified antibody |
antibody product type | primary antibodies |
克隆 | 6C5.1, monoclonal |
species reactivity | human |
technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
同位素/亚型 | IgG2aκ |
NCBI登记号 | NP_002044 |
UniProt登记号 | P32455 |
运输 | wet ice |
Gene Information | human ... GBP1(2633) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |