产品说明
一般描述
HDAC2 is a member of the deacetylase family that forms transcriptional repressor complexes. Studies have reported that HDAC2 negatively regulates synaptic plasticity, learning and memory functions. In colorectal carcinogenesis, loss of APC is known to induce HDAC2 expression.
Rabbit Anti-HDAC2 recognizes bovine, human, canine, chicken, rat, and mouse HDAC2.
免疫原
Synthetic peptide directed towards the C terminal region of human HDAC2
应用
Rabbit Anti-HDAC2 antibody can be used for western blot (0.2-2.0μg/ml) and IHC (4-8μg/ml) applications.
生化/生理作用
Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly concerved from yeast to human.
序列
Synthetic peptide located within the following region: EEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSK
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD02096533 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 55 kDa |
| species reactivity | rat, human, rabbit, pig, dog, mouse, bovine |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_001518 |
| UniProt登记号 | Q92769 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... HDAC2(3066) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
