产品说明
一般描述
Granzyme K (GZMK) also known as tryptase 2 (TRYP2), is a trypsin like serine protease, evolutionarily similar to granzyme A (GZMA). In human chromosome, the gene GZMK is localized on 5q11.2.
免疫原
Synthetic peptide directed towards the middle region of human GZMK
生化/生理作用
GZMK is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes and natural killer cells. GZMK cleave after the basic amino acids like arginine or lysine. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface ′nonself′ antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. Gmzk expression level is higher in patients with sepsis and also in bronchoalveolar fluid with respiratory infections. GzmK can cause apoptosis by DNA fragmentation, and also by ROS (reactive oxygen species) production. GzmK triggers cleavage of p53, a proapoptotic protein and that potentiates apoptosis of tumor cells. Gzmk is highly expressed in NK cells and plays a key role in NK cells mediated tumor cell clearance. β-tubulin, a component of microtubule network is cleaved by Gzmk, which is crucial for maintaining the cell shape, mitosis and the intracellular trafficking.
序列
Synthetic peptide located within the following region: LRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKLCNSQSYYNGDPF
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 26 kDa |
| species reactivity | human |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NM_002104 |
| UniProt登记号 | P49863 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... GZMK(3003) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
