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Anti-GPC4 (N-term) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1300308
规格纯度
saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
参考价格
4618.16 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

GPC4 (glypican-4) gene is mapped to human chromosome Xq26.2. The encoded protein is a heparan sulfate proteoglycan and localizes to membrane microdomains.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3′ end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.

免疫原

GPC4 (NP_001439, 30-66)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human GPC4.

生化/生理作用

GPC4 (glypican-4) is associated with a number of signaling mechanisms involving growth factors. GPC4 influences cell proliferation, by serving as a co-receptor for growth factors. It regulates the Wnt signaling pathway. GPC4 might be associated with epileptic seizures, with this gene upregulated in the brain. GPC4 is an adipokine and is known to enhance insulin signaling and regulate adipocyte differentiation. Overexpression of this gene in polycystic ovary syndrome might be associated with the risk of cardiovascular disease.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式saturated ammonium sulfate (SAS) precipitated
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
NCBI登记号NP_001439
UniProt登记号O75487
运输dry ice
储存温度−20℃
Gene Informationhuman ... GPC4(2239)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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