产品说明
一般描述
Golph3 (Golgi phosphoprotein 3), also known as coat protein GPP34, is a peripheral membrane protein of the Golgi stack, that localizes to the trans-Golgi network. It is an oncogene that is commonly targeted for amplification in human cancer and in cancer cell lines.
免疫原
peptide corresponding to the N-terminal region of human Golph3, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey and bovine.
应用
Anti-Golph3 (N-terminal) antibody produced in rabbit has been used in:
- immunoprecipitation
- immunofluorescence
- immunoblotting
生化/生理作用
Golph3 (Golgi phosphoprotein 3) is important for Golgi trafficking and morphology by interacting with the unconventional myosin MYO18A, linking Golgi membranes to the actin cytoskeleton. It is a phosphatidylinositol-4-phosphate (PtdIns(4)P binding protein required for Golgi function. GOLPH3 overexpression is correlated with hyperactivation of mTOR signaling, in human cells.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~34 kDa |
| species reactivity | mouse, human |
| 浓度 | ~1.0 mg/mL |
| technique(s) | immunoprecipitation (IP): 5-10 μg using lysates of human HeLa cells indirect immunofluorescence: 2.5-5.0 μg/mL using mouse 3T3 cells western blot: 1-2 μg/mL using whole extracts of human HeLa cells |
| UniProt登记号 | Q9H4A6 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... GOLPH3(64083) mouse ... Golph3(66629) rat ... Golph3(78961) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
