产品说明
一般描述
Glutaredoxin-1 (Grx1) is encoded by the gene mapped to human chromosome 5q15. The encoded protein is a sulfhydryl disulfide oxidoreductase enzyme with a molecular mass of 12kDa. Grx1 belongs to the oxidoreductase family. Grx is expressed in various types of mammalian cells including human placenta and erythrocytes.
Anti-Glutaredoxin-1 is produced in rabbit using as immunogen a human glutaredoxin-1 recombinant protein (G5298), conjugated to KLH. GRX1 is found in the cytosol and supplies ribonucleotide reductase with electrons.
免疫原
human glutaredoxin-1 recombinant protein conjugated to KLH
应用
Anti-Glutaredoxin-1 antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
Glutaredoxin (Grx) catalyzes glutathione (GSH)-dependent disulfide reductions when coupled to GSH, NADPH and glucocorticoid receptor (GR). Grx1 is implicated in various cellular processes, such as anti-oxidation, anti-apoptosis and regulation of cell differentiation. Additionally, the encoded protein also protects the retinal pigment epithelial (RPE) cells from H2O2-induced apoptosis by inhibiting protein kinase B (AKT) glutathionylation. Thus, Grx1 can be used as a potential therapeutic target for retinal degenerative diseases.
GRX1 is involved in general disulfide-dithiol exchanges, dehydroascorbate reduction and regulation of transcription factors.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | Ig fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~12 kDa |
| species reactivity | human |
| technique(s) | western blot: 1:500-1:1000 using whole extracts of human HepG2 cells |
| UniProt登记号 | P35754 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... GLRX(2745) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
