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Anti-GluR2/GRIA2 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700955
包装型号
规格纯度
参考价格
4668.88 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

免疫原

A synthesized peptide derived from human GluR2/GRIA2

外形

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

产品性质

生物来源rabbit
质量水平100
antibody product typeprimary antibodies
克隆monoclonal
形式liquid
species reactivitymouse, human, rat
浓度1.3 mg/mL
technique(s)immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000
UniProt登记号P42262
运输wet ice
储存温度−20℃
Gene Informationhuman ... GRIA2(2891)

安全信息

闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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