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Anti-GLUR2 pS880 (Clone 022.19.5) Antibody

品牌
Sigma-Aldrich
货号
MABN103
规格纯度
clone 022.19.5, from mouse
参考价格
6190.47 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Although subunit composition of AMPA receptors varies, they must contain at least one edited GluR2 subunit to be calcium impermeable. Ser880 has been identified as the protein kinase C (PKC) phosphorylation site within the C-terminal region of GluR2 and has been shown to differentially regulate the interaction of the PDZ domain-containing proteins GRIP1 and PICK 1. In addition, PKC phosphorylation of GluR2 Ser880 appears to be a critical event in the induction of cerebellar long term depression (LTD).

特异性

This antibody recognizes GluR2 phosphorylated at Ser880.

免疫原

KLH-conjugated linear peptide corresponding to rat GluR2 phosphorylated at Ser880.
Epitope: Phosphorylated Ser880

应用

Research Sub Category
Neurotransmitters & Receptors

Neurodegenerative Diseases
This Anti-GLUR2 pS880 (Clone 022.19.5) Antibody is validated for use in WB for the detection of GLUR2 pS880 (Clone 022.19.5).
Research Category
Neuroscience

质量

Evaluated by Western Blot in lambda phosphatase treated and untreated rat hippocampus tissue lysates.

Western Blot Analysis: 1 µg/mL of this antibody detected GluR2 on 10 µg of lambda phosphatase untreated rat hippocampus tissue lysate.

目标描述

~100 kDa observed

外形

Format: Purified
Protein G
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Lambda phosphatase treated and untreated rat hippocampus tissue lysates

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified antibody
antibody product typeprimary antibodies
克隆022.19.5, monoclonal
species reactivityrat
technique(s)western blot: suitable
同位素/亚型IgG2aκ
NCBI登记号NP_001077280
UniProt登记号P19491
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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