产品说明
一般描述
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3′-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. (provided by RefSeq)
Ras-GAP SH3-domain binding protein stress granule assembly factor 1 (G3BP1) is encoded by the gene mapped to human chromosome 5q33.1– 5q33.3. The encoded protein is composed of 466 amino acids and is a member of the G3BP family. G3BP1 contains an N-terminal nuclear transport factor 2 (NTF2)-like domain, a minimal putative Src homology 3 (SH3) domain binding sequence and an acid rich domain. In addition, it also contains two domains commonly found in RNA binding proteins, an RNA recognition motif (RRM) and an arginine/glycine rich (RGG) domain.
免疫原
G3BP1 (NP_005745.1, 1 a.a. ~ 466 a.a) full-length human protein.
Sequence
MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVSNDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQTVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRDQRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFFQSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ
生化/生理作用
G3BP stress granule assembly factor 1 (G3BP1) plays a vital role in Ras signaling, nuclear factor κB (NFκB) signaling, the ubiquitin proteasome pathway and RNA processing. G3BP1 is also implicated in cancer formation or progression. The encoded protein is required for stress granule (SG) - processing body (PB) interactions and normal SG assembly. G3BP1 inhibits human immunodeficiency virus-1 (HIV-1) replication by binding and sequestering HIV-1 transcripts inside cytosolic organelles.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~52.2 kDa |
| species reactivity | human |
| technique(s) | indirect immunofluorescence: suitable western blot: 1 μg/mL |
| NCBI登记号 | NM_005754 |
| UniProt登记号 | Q13283 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... G3BP1(10146) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
