Anti-FOXL2 Antibody

产品说明

一般描述

Forkhead box protein L2 (FOXL2) is a fork-head transcription factor that is expressed in developing gonad and in granulosa cells of the mature ovary. It plays a role in repressing the development of testis, and facilitating the differentiation and maintenance of the ovary. Mutations in the FOXL2 gene result in blepharophimosis ptosis epicanthus inversus (BPES) syndrome, which is characterized by craniofacial defects and premature ovarian failure. FOXL2 has also been implicated in the development of ovarian granulosa cell tumors.

特异性

Other homologies: Chicken (77% sequence homology).

免疫原

KLH-conjugated linear peptide corresponding to human FOXL2.

应用

This Anti-FOXL2 Antibody is validated for use in Western Blotting for the detection of FOXL2.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology

质量

Evaluated by Western Blot in human pituitary tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected FOXL2 in 10 µg of human pituitary tissue lysate.

目标描述

~50 kDa observed. An uncharacterized band may appear at ~25 kDa in some lysates. The calculated molecular weight is 39 kDa, however FOXL2 has been shown as a ~50 kDa band in western blots (Marongiu, M., et al. (2010). PLOS One. 5(3):1-9).

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human pituitary

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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