产品说明
一般描述
Folliculin (FLCN) is a protein with many possible roles. Folliculin may play a role in the pathogenesis of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). But, Folliculin (FLCN) may be a tumor suppressor, however it is also involved in the generation of colorectal tumorigenesis and renal cell carcinoma, and finally Folliculin (FLCN) might be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Mutations of Folliculin (FLCN) give rise to Birt-Hogg-Dube syndrome, a rare autosomal dominant genodermatosis characterized by hair follicle hamartomas (fibrofolliculomas), kidney tumors, and spontaneous pneumothorax disorders. Folliculin (FLCN) is widely expressed and localized in both the cytoplasm and nucleus depending upon the conditions in both the fetus and the adult.
免疫原
GST-tagged recombinant protein corresponding to human Folliculin (FLCN).
应用
Research Sub Category
Apoptosis - Additional
This Anti-Folliculin (FLCN), Antibody clone 8D9.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of Folliculin (FLCN).
Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected Folliculin (FLCN) in HeLa cells.
Alexa Fluor® is a registered trademark of Life Technologies
Research Category
Apoptosis & Cancer
质量
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Folliculin (FLCN) in 10 µg of HeLa cell lysate.
目标描述
~65 kDa observed.
外形
Purified by Ion-Exchange Chromatography
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
法律信息
ALEXA FLUOR is a registered trademark of Life Technologies
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 8D9.2, monoclonal |
| species reactivity | human |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| 同位素/亚型 | IgMκ |
| NCBI登记号 | NP_653207 |
| UniProt登记号 | Q8NFG4 |
| 运输 | wet ice |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
