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Anti-FNIP2 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB3500010
规格纯度
affinity isolated antibody, buffered aqueous solution, ab2
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Folliculin interacting protein 2 (FNIP2) is a 125.6kDa protein expressed in the cytoplasm.

免疫原

FNIP2 antibody was raised against an 18 amino acid peptide near the amino terminus of human FNIP2.

生化/生理作用

Folliculin interacting protein 2 (FNIP2) induces apoptosis. It associates with AMP-activated protein kinase (AMPK) and folliculin (FLCN). The protein also has a role in the O6-methylguanine-induced apoptosis signaling pathway.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship. Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.

联系

The action of this antibody can be blocked using blocking peptide SBP3500010.

外形

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivitymouse, human, rat
technique(s)indirect ELISA: suitable
western blot: suitable
NCBI登记号NP_065891
UniProt登记号Q9P278
运输dry ice
储存温度−20℃
Gene Informationhuman ... FNIP2(57600)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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