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Anti-Fetuin A antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200820
规格纯度
clone FetA-M, purified from hybridoma cell culture
参考价格
2067.58 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Fetuin A, also known as Alpha-2-HS-glycoprotein (AHSG), Alpha-2-Z-globulin or Ba-alpha-2-glycoprotein, is a member of the cystatin superfamily of cysteine protease inhibitors. Fetuin A is a secreted calcium-regulatory glycoprotein produced by liver Hepatocytes. It is cleaved into two chains bound by disulfide bonds and inhibits ectopic Ca×PO4 ion precipitation and vascular calcification.
Monoclonal Anti-Fetuin A (mouse IgM isotype) is derived from the Fet A-M hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a BALB/C mouse immunized with a synthetic peptide corresponding to the internal region of human AHSG (Fetuin A), conjugated to KLH as immunogen. Fetuin A is a 64 kDa protein, predominantly localized to the blood.

特异性

Monoclonal Anti-Fetuin A specifically recognizes Fetuin A from human plasma.

免疫原

Synthetic peptide corresponding to human Fution A internal region, conjugated to KLH

应用

The antibody is recommended for use in various immunological techniques including Immunoblotting, Immunohistochemistry and ELISA.

生化/生理作用

Fetuin A is consider to be a negative acute-phase reactant and its serum concentration decreases in response to inflammation, compared with normal levels. In addition, it acts as a mineral chaperone to facilitate the transport and removal of potentially proinflammatory and procalcific cargo (waste).Fetuin A plays a major role in numerous diseases and pathophysiological conditions involved with calcium metabolisms.
Fetuin A is a secreted calcium-regulatory glycoprotein produced by liver hepatocytes. It is cleaved into two chains bound by disulphide bonds and inhibits ectopic Ca×PO4 ion precipitation and vascular calcification.
Reduction in the serum fetuin might indicate coronary artery disease. Fetuin is also implicated in insulin resistance and metabolic syndrome. Increased levels of fetuin A is observed in non-alcoholic fatty liver disease.

外形

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

储存及稳定性

For continuous use, store at 2-8℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog  our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源mouse
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆FetA-M, monoclonal
species reactivityhuman
包装antibody small pack of 25 μL
浓度~1 mg/mL
technique(s)immunoblotting: 2-4 μg/mL using Human serum
同位素/亚型IgM
UniProt登记号P02765
运输dry ice
储存温度−20℃
Gene Informationhuman ... AHSG(197)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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