产品说明
一般描述
Exendin-4 is an incretin mimetic 39-amino-acid peptide found in venom from the Gila monster (Helicoderma suspectum). Exendin-4 belongs to the glucagon-secretin family of peptide hormones and neuropeptides. It acts as a potent agonist of the GLP-1 receptor and is an insulinotropic agent (promotes insulin secretion) with a long half-life.
Exendin-4 mimics the activity of mammalian incretin hormone glucagon-like peptide 1 (GLP-1) and thus play a role in the control of glucose. This includes the secretion of insulin in a glucose-dependent manner, negative regulation of high glucagon secretion, and increased duration of stomach emptying. In type 2 diabetes patients, this peptide can be administered subcutaneously for glycemic control, when metformin is unable to produce adequate results. Exendin-4 promotes the neogeneration and proliferation of β-cells, and thus aids in the regeneration of pancreas. It acts as a ligand to exendin receptor and leads to an elevation of acinar cell cAMP levels.
Anti-Exendin-4 antibody specifically recognizes synthetic Exendin-4 and does not cross react with GLP-1.
免疫原
synthetic peptide corresponding to the C-terminal sequence of Heloderma suspectum (Gila monster) Exendin-4 , conjugated to KLH
应用
The antibody may be used in various immunochemical techniques including ELISA
外形
Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
其他说明
This product is for R&D use only, not for drug, household, or other uses.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 浓度 | ~1 mg/mL |
| technique(s) | indirect ELISA: 0.125-0.25 μg/mL using 1 μg/mL Exendin-4 protein for coating |
| UniProt登记号 | P26349 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
