Anti-ERR-alpha P2 Antibody

产品说明

一般描述

ERR alpha is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site specific transcription regulator and has also been shown to interact with estrogen and the transcription factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium chain acyl coenzyme A dehydrogenase (MCAD),and thyroid hormone receptor genes. ERR alpha is expressed in many adult and embryonic tissues (particularly at the onset of ossification) as well as in several osteoblast cell lines. ERR alpha expression has been documented in brain, spinal cord, pituitary gland and heart. More recently, ERR alpha has been observed in various human breast cancer cell lines, breast adipose tissue and breast tumors. Studies demonstrating the use of ERR alpha antagonists in treating breast cancer have excited great interest in this receptor in the search for curing the disease (Chisamore, 2009).

特异性

This antibody recognizes ERR-alpha.

免疫原

KLH-conjugated linear peptide corresponding to human ERR-alpha.

应用

Use Anti-ERR-alpha P2 Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect ERR-alpha P2 also known as Estrogen receptor-like 1, Estrogen-related receptor alpha.
Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected ERR-alpha in A431 and HeLa cells.

质量

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected ERR-alpha on 10 µg of HeLa cell lysate.

目标描述

~ 53 kDa

联系

Replaces: 04-1134

外形

Protein A purified
Format: Purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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