产品说明
一般描述
The enzyme DIO3 is a critical enzyme in thyroid hormone metabolism. It converts the thyroid hormone T4 into the inactive form RT3 and it also converts the thyroid hormone T3 into the inactive form T2. It is thought that DIO3 plays a role in preventing premature exposure of the developing fetus to adult levels of thyroid hormones. DIO3 also regulates the levels of fetal thyroid hormones during gestation, thus DIO3 is critical for proper development and metabolism of the fetus during embryological development. DIO3 is expressed in the placenta and in fetal tissues, and DIO3 is localized to the cell membrane and endosomal membranes. DIO3 is also often expressed in neoplastic tissues and in particular basal cell carcinomas.
免疫原
BSA-conjugated linear peptide corresponding to the extracellular domain of human Dio3.
Epitope: Extracellular domain
应用
Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Dio3 in human placenta.
Immunohistochemistry Analysis: A representative lot detected Dio3 in Hepatic tissue (Huang, S.A., et al. (2001). Journal of Clinical Endocrinology & Metabolism. 87(10):4457–4461).
Immunohistochemistry Analysis: A representative lot detected Dio3 in human uterus, placenta, umbilical cord, fetal epithelial, and endometrium (Huang, S.A., et al. (2003). Journal of Clinical Endocrinology & Metabolism. 88(3):1384-1388).
Anti-Dio3 Antibody is an antibody against Dio3 Antibody for use in Immunohistochemistry, Immunofluorescence.
Research Category
Signaling
Research Sub Category
Signaling Neuroscience
质量
Evaluated by Immunohistochemistry in human uterus tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Dio3 in human uterus tissue.
目标描述
34 kDa calculated
外形
Affinity purified
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 纯化方式 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | primate (based on 100% sequence homology) |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable |
| GenBank® accession no. | AAB35616 |
| UniProt登记号 | P55073 |
| 运输 | wet ice |
| Gene Information | human ... DIO3(1735) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
