产品说明
一般描述
Cytochrome P450 family 17 subfamily A member 1 (CYP17A1) is a member of the cytochrome P450 superfamily of enzymes. It is encoded by the gene mapped to human chromosome 10q24.32. This protein localizes to the endoplasmic reticulum.
免疫原
CYP17A1 (NP_000093, 363-398)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human CYP17A1.
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
生化/生理作用
Cytochrome P450 family 17 subfamily A member 1 (CYP17A1) catalyzes 17Α-hydroxylation of steroid substrates and cleavage and oxidation of their side-chains. It has both 17Α-hydroxylase and 17, 20-lyase activities. The protein acts as a key enzyme in the synthesis of cortisol, testosterone and oestrogen. Mutations in CYP17A1 gene are associated with mineralocorticoid excess syndromes, glucocorticoid and sex hormone deficiencies. In addition, it also increases the risk of susceptibility to prostate cancer, benign prostatic hypertrophy and occasional congenital adrenal hyperplasia (CAH). Abiraterone inhibits steroidogenic activity of CYP17A1 and retards tumor growth in castration-resistant prostate cancer (CRPC) patients.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | saturated ammonium sulfate (SAS) precipitated |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | indirect ELISA: 1:1000 western blot: 1:100-1:500 |
| NCBI登记号 | NP_000093 |
| UniProt登记号 | P05093 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CYP17A1(1586) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
