产品说明

一般描述

CREBZF (cAMP response element binding bZIP (basic leucine zipper) transcription factor), also called as zhangfei (ZF) or small heterodimer partner interacting leucine zipper protein (SMILE), belongs to the mammalian activating transcription factor (ATF) or CREB (cAMP response element binding) transcription factor family. CREBZF gene is mapped to human chromosome 11q14.1.

免疫原

CREB/ATF bZIP transcription factor recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

CREBZF (cAMP response element binding bZIP transcription factor) might function as an amino acid stress sensor, which helps in controlling various signaling pathways regulating amino acid response (AAR). CREBZF takes part in DNA damage stress responses by controlling the p53 pathway.This protein, upon interaction with host cell factor C1 (HCFC1), helps in transcription activation of herpes simplex virus genes. CREBZF protein regulates the action of NGF (nerve growth factor) by activating the expression of its high-affinity receptor tropomyosin-related kinase (trkA).

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST73715.

外形

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

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