Anti-C9orf72 antibody produced in rabbit

产品说明

一般描述

Chromosome 9 open reading frame 72 (C9orf72) gene is mapped to human chromosome 9p21.
C9orf72 (chromosome 9 open reading frame 72) is a DENN domain containing protein. It is expressed in neuronal cell lines. It has been reported that C9orf72 colocalizes with Rab proteins, which indicates its role in autophagy and endocytic transport pathways.

特异性

Anti-C9orf72 recognizes human C9orf72.

免疫原

synthetic peptide corresponding to the N-terminal region of human C9orf72

应用

Anti-C9orf72 antibody produced in rabbit may be used in:

• immunoblotting
• immunocytochemistry
• immunohistochemistry

生化/生理作用

C9orf72 (chromosome 9 open reading frame 72) maintains a physical interaction with Rab proteins during autophagy, cellular trafficking and protein degradation. The cellular activities of the protein are not well defined. It has been reported that mutations of C9orf72 gene are associated with amyotrophic lateral sclerosis (ALS) with degeneration of upper and lower motor neurons in the brain, brainstem and spinal cord, leading to progressive paralysis and frontotemporal dementia.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

储存及稳定性

For continuous use, store at 2–8 ℃ for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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