产品说明
一般描述
Complement factor H (CFH) codes for 20 complement-control protein modules (CCPs 1–20). It is expressed in the liver, mesangial cells, endothelial cells and fibroblasts. It is a membrane cofactor protein. The CFH gene is localized on human chromosome 1q31.3.
免疫原
Peptide with sequence C-HLVPDRKKDQYK from the internal region of the protein sequence according to NP_000177.2.
生化/生理作用
Complement factor H (CFH) is a negative regulator of the alternative pathway. It suppresses spontaneous complement activation and its response on self surfaces. CFH possesses decay-accelerating activity and destabilizes the C3b amplification in the alternate complement pathway. It also has a role in C3b cleavage by its cofactor activity. The protein has been linked to various diseases like age-related macular degeneration, kidney disorder and C3 glomerulopathy. CFH might prevent complement activation in ischemic renal injury by binding to tubular epithelial cells.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
产品性质
| 质量水平 | 100 |
| 生物来源 | goat |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable indirect ELISA: suitable western blot: suitable |
| UniProt登记号 | P08603 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CFH(3075) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
