产品说明
一般描述
Cytidine/uridine monophosphate kinase 2 (CMPK2) is expressed in mitochondria. The protein Cmpk2 is similar to thymidylate kinase than to cytosolic Cmpk1. Cmpk2 has thymidylate kinase domain and the C-terminal domain contains all the consensus motifs: P-loop (ATP/ GTP binding motif A), LID (domain in lipase) domain, adenine-base binding loop, catalytic site, and potential substrate binding site. In human chromosome, the gene is localized on 2p25.2.
生化/生理作用
Cmpk2 utilizes ATP (adenosine triphosphate) as phosphate donor to phosphorylate dUMP (deoxyuridine monophosphate), dCMP (deoxycytidine monophosphate), CMP (cytosine monophosphate), and UMP (uridine monophosphate). The order of substrate specificity for Cmpk2 is UMP, the highest, followed by dCMP, CMP and UMP. Cmpk2 also phosphorylates monophosphate nucleoside analogs ddC (zalcitabine), dFdC (gemcitabine), araC (vidarabine), BVDU (brivudine), and FdUrd (fluorodeoxyuridine). Cmpk2 expression is found in leukemic cells like chronic myelogenous leukemia K-562 and lymphoblastic leukemia MOLT-4, implicates its pathophysiology. The catalytic activity of Cmpk2 is similar to human adenylate kinase 9.
特点和优势
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联系
The action of this antibody can be blocked using blocking peptide SBP3500816.
外形
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | predicted mol wt 49 kDa |
| species reactivity | human, rat, mouse |
| technique(s) | ELISA: suitable immunofluorescence: suitable western blot: suitable |
| UniProt登记号 | Q5EBM0 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CMPK2(129607) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
