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Anti-Claudin-1 (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200534
规格纯度
~1.0 mg/mL, affinity isolated antibody
参考价格
4283.07 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Claudin-1, also known as claudin 1 (CLDN1), seminal metalloprotease-1 (Semp1) and ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC), is expressed at high levels in kidney and liver and at lower levels in spleen, heart, brain, lung and testis. Claudins are characterized with four transmembrane domains and two extracellular loops, required to form tight junction strands.

免疫原

synthetic peptide corresponding to a sequence at the C-terminus of human claudin-1, conjugated to KLH. The corresponding sequence is highly conserved in mouse claudin-1 (single amino acid substitution) and in rat claudin-1 (90% identity).

应用

Anti-Claudin-1 (C-terminal) antibody produced in rabbit has been used in:

  • immunoblotting
  • immunofluorescence
  • immunohistochemistry

生化/生理作用

Claudin-1 directly interacts with tight junction (TJ) -associated peripheral membrane proteins zonula occludens (ZO) proteins -1/2/3. Defects in the gene encoding claudin-1 are the cause of an autosomal recessive syndrome named ichthyosis-sclerosing cholangitis neonatal (NISCH). Claudins′ expression is altered in several human cancers. Claudin-1 is frequently up-regulated in colorectal carcinomas (CRCs), resulting in tumor differentiation and progression.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~23 kDa
species reactivitydog, human
增强验证recombinant expression
Learn more about Antibody Enhanced Validation
浓度~1.0 mg/mL
technique(s)immunohistochemistry: 20 μg/mL using formalin-fixed, paraffin-embedded human colon.
indirect immunofluorescence: 1.0-2.0 μg/mL using MDCK cells.
western blot: 0.5-1.0 μg/mL using extracts of HEK-293T cells overexpressing human claudin-1.
UniProt登记号O95832
运输dry ice
储存温度−20℃
Gene Informationhuman ... CLDN1(9076)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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