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Anti-Chromogranin A antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200668
规格纯度
affinity isolated antibody
参考价格
6092.23 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

CHGA (chromogranin A) is a granin family acidic glycoprotein. It resides in endocrine and neuroendocrine cells, where it is localized to secretory dense-core granules which store peptide hormones. It is a predominant protein of the chromaffin cell secretory granules.

免疫原

synthetic peptide corresponding to the GR-44 peptide in the C-terminal region of human Chromogranin-A , conjugated to KLH.

应用

Anti-Chromogranin A antibody produced in rabbit has been used in immunohistochemistry.

生化/生理作用

CHGA (chromogranin A) is secreted in abnormal levels by neoplastic neuroendocrine cells, which might be linked with tumor growth and progression, as it might influence the different components of tumor stroma. It is a highly sensitive and specific biomarker for the diagnosis of NETs (neuroendocrine tumors). CHGA is processed to produce catestatin (CST), vasostatin-I, serpinin and pancreastatin (PST), which function as metabolic or cardiovascular-regulatory peptides. As this protein is co-stored and co-released with catecholamines, it plays an essential role in production of catecholamine storage vesicles. It functions as a circulating biomarker for gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) patients.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
形式buffered aqueous solution
species reactivityhuman
浓度~1 mg/mL
technique(s)immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human pancreas sections
UniProt登记号P10645
运输dry ice
储存温度−20℃
Gene Informationhuman ... CHGA(1113)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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