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Anti-CD11c Antibody (human), clone 3.9

品牌
Sigma-Aldrich
货号
MABF370
规格纯度
clone 3.9, 0.5 mg/mL, from mouse
参考价格
3841.74 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The 3.9 antibody reacts with human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The 3.9 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on activated neutrophils, granulocytes, some types of activated T cells and intestinal intraepithelial lymphocytes (IEL). The antibody is reported to be cross-reactive with Baboon, Chimpanzee, Cynomolgus and Rhesus CD11c.

特异性

Toxicity: Highly Toxic (H)

免疫原

Immunogen information for this antibody is proprietary information.

应用

This Mouse Monoclonal Antibody Anti-CD11c (human), clone 3.9, Cat. No. MABF370 is validated for use in Immunoprecipitation, Immunofluorescence, Flow Cytometry for the detection of CD11c.
Research Category
Inflammation & Immunology

外形

Purified Mouse Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Format: Purified

储存及稳定性

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified antibody
antibody product typeprimary antibodies
克隆3.9, monoclonal
species reactivityhuman
浓度0.5 mg/mL
technique(s)flow cytometry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
同位素/亚型IgG1κ
UniProt登记号P20702
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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