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Anti-CD11c Antibody (human), APC, clone 3.9

品牌
Sigma-Aldrich
货号
MABF521
规格纯度
clone 3.9, from mouse
参考价格
2332.34 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The 3.9 antibody reacts with human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells. The 3.9 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on activated neutrophils, granulocytes, some types of activated T cells and intestinal intraepithelial lymphocytes (IEL). The antibody is reported to be cross-reactive with Baboon, Chimpanzee, Cynomolgus and Rhesus CD11c.

免疫原

Immunogen information for this antibody is proprietary information.

应用

This mouse monoclonal antibody Anti-CD11c (human), APC & clone 3.9 validated for use in IP;Immunofluorescence;Flow Cytometry for the detection of CD11c.
Research Category
Inflammation & Immunology

质量

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.25 µg of this antibody detected CD11c in one million human peripheral blood monocytes.

外形

Size Exclusion Chromatography
Purified mouse monoclonal antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

储存及稳定性

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物Allophycocyanin conjugate
抗体形式purified antibody
antibody product typeprimary antibodies
克隆3.9, monoclonal
species reactivityhuman
包装pkg of 5 μL (0.25 μg/test)
technique(s)flow cytometry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
同位素/亚型IgG1κ
UniProt登记号P20702
运输wet ice
Gene Informationhuman ... ITGAX(3687)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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