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Anti-CD43 antibody, Rabbit monoclonal

品牌
Sigma-Aldrich
货号
SAB5500067
规格纯度
clone SP55, recombinant, expressed in proprietary host, affinity isolated antibody
参考价格
4267.14 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The SPN (sialophorin) gene is mapped to human chromosome 16p11.2 and encodesa transmembrane sialoglycoprotein cluster of differentiation 43 (CD43). It is localized to the surface of leukocytes and is expressed in hematopoietic cells. CD43 protein structure possesses a 23-amino acid transmembrane bridge connecting the N- and C- terminal regions. Its cytoplasmic tail is highly conserved.
CD43 is one of the major glycoproteins of thymocytes and T lymphocytes. It plays a role in the physicochemical properties of the T cell surface and in lectin binding. CD43 presents carbohydrate ligands to selectins. It has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. The antigen is a counter receptor for SN/Siglec1. During T cell activation CD43 is actively removed from the T cell antigen presenting cell contact site suggesting a negative regulatory role in adaptive immune response.

免疫原

Synthetic peptide derived from the human CD43.

应用

Anti-CD43 antibody, Rabbit monoclonal has been used in immunohistochemistry.

生化/生理作用

Cluster of differentiation 43 (CD43) is known to regulate cell cycle and cell relocation in both lymphoid and non-lymphoid tumor cells. It serves as a biomarker in chronic lymphocytic leukemia and other hematologic cancer diagnosis. CD43 is associated with cell movement, cell differentiation, apoptosis and immune homeostasis. Glycosylation and sialylation of CD43 at extracellular C-terminus, enables its purpose as a ligand for selectins. CD43 promotes extracellular signal-regulated kinase 1/2 (ERK 1/2) signaling, which is necessary for actin cytoskeleton modifications. CD43 is associated with autoimmune diseases, including systemic lupus erythematosus, diabetes, human immunodeficiency virus (HIV) infection and Wiskott-Aldrich syndrome.

特点和优势

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外形

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
重组expressed in proprietary host
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆SP55, monoclonal
species reactivityhuman (tested)
technique(s)flow cytometry: 1:100
immunoblotting: 1:25
immunohistochemistry: 1:200
同位素/亚型IgG
UniProt登记号P16150
运输wet ice
储存温度2-8℃
Gene Informationhuman ... SPN(6693)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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