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Anti-CD127 (IL-7Ra) Antibody (mouse), APC, clone A7R34

品牌
Sigma-Aldrich
货号
MABF535
规格纯度
clone A7R34, 0.2 mg/mL, from rat
参考价格
1295.39 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).

免疫原

Immunogen information for this antibody is proprietary information.

应用

This rat monoclonal antibody Anti-CD127 (IL-7Ra) (mouse), APC, clone A7R34 validated for use in IP, Flow Cytometry & IHC for the detection of CD127 (IL-7Ra).
Research Category
Inflammation & Immunology

质量

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.25 μg of this antibody detected CD127 (IL-7Ra) in one million C57Bl/6 splenocytes.

外形

Size Exclusion Chromatography
Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

储存及稳定性

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源rat
偶联物Allophycocyanin conjugate
抗体形式purified antibody
antibody product typeprimary antibodies
克隆A7R34, monoclonal
species reactivitymouse
包装antibody small pack of 25 μg
浓度0.2 mg/mL
technique(s)flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型IgG2aκ
UniProt登记号P16872
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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