产品说明
一般描述
CASQ1 (calsequestrin 1) gene encodes a member of the calsequestrin protein family. The gene is mapped to human chromosome 1q21, a region that has been associated with type 2 diabetes in certain populations.
免疫原
Calsequestrin-1 precursor recombinant protein epitope signature tag (PrEST)
应用
Anti-CASQ1 antibody produced in rabbit has been used for global protein profiling to find new molecular biomarkers for common, multifactorial disorders.
Anti-CASQ1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
生化/生理作用
CASQ1 (calsequestrin 1) gene encodes a protein localized in the sarcoplasmic reticulum of fast-twitch skeletal muscle cells. It functions as a calcium storage protein regulating calcium flux via calcium channel activity control and interaction with other proteins present in the sarcoplasmic reticulum. The calcium that is released into the cytosol from the sarcoplasmic reticulum regulates the expression of GLUT4 and glucose transport in muscle. Mutations in this gene may affect insulin action on glucose uptake and glycogen synthesis in skeletal muscle and increase susceptibility to type 2 diabetes.
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST70700.
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律信息
Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC
基本信息
| MDL编号 | MFCD09265355 |
| 人类蛋白质图谱编号 | HPA007845 Human Protein Atlas characterization data |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 产品线 | Prestige Antibodies® Powered by Atlas Antibodies |
| 形式 | buffered aqueous glycerol solution |
| species reactivity | human |
| 增强验证 | recombinant expression orthogonal RNAseq Learn more about Antibody Enhanced Validation |
| technique(s) | immunoblotting: 0.04-0.4 μg/mL immunohistochemistry: 1:20-1:50 |
| 免疫原序列 | LDFPEYDGVDRVINVNAKNYKNVFKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLTEVDSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIGY |
| UniProt登记号 | P31415 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CASQ1(844) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
