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Anti-Betacellulin Antibody, clone 6G10.1

品牌
Sigma-Aldrich
货号
MABS458
规格纯度
clone 6G10.1, from mouse
参考价格
5016.79 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The human BTC gene (Gene ID 685) encodes the 178 aa preprobetacellulin (UniProt P35070) protein. Post-translatioinal removal of the signal peptide (aa 1-31) produces probetacellulin (aa 32-178), which further matures into the 80 aa betacellulin (aa 32-111) following propeptide (aa 112-178) removal. Betacellulin is an EGF family growth factor with a higher affinity and specificity for ErbB1/EGFR and ErbB4. Betacellulin plays an important role in the development of the acute exacerbations of chronic obstructive pulmonary disease. Betacellulin is also reported to induce CXCL8 (IL-8) production from human lung cancer cells through EGFR–PI3K–Akt–ERK pathway activation, resulting in the recruitment of inflammatory cells in the cancer tissue and creating an inflammatory tumor microenvironment.

特异性

Clone 6G10.1 is expected to detect prepro-, pro-, and mature betacellulin.

免疫原

Epitope: Mature betacellulin
GST-tagged human recombinant full-length mature betacellulin.

应用

This Anti-Betacellulin Antibody, clone 6G10.1 is validated for use in Western Blotting, Immunohistochemistry for the detection of Betacellulin .
Research Category
Signaling
Research Sub Category
Signaling Neuroscience
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Betacellulin in human pancreas tissue.

质量

Evaluated by Western Blotting in human pancreas tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Betacellulin in 10 µg of human pancreas tissue lysate.

目标描述

~20 kDa observed. Preprobetacellulin (19.7 kDa calculated); Probetacellulin (16.6 kDa calculated); Betacellulin (9.0 kDa calculated). Due to posttranslational glycosylation, target band(s) will migrate with a higher apparent M.W. than caluclated.

外形

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆6G10.1, monoclonal
species reactivityhuman
technique(s)immunohistochemistry: suitable
western blot: suitable
同位素/亚型IgG1κ
NCBI登记号NP_001720
UniProt登记号P35070
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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