产品说明
一般描述
Bcl-2(B-cell lymphoma 2)-like protein 11 (BCL2L11) also known as Bcl-2 interacting mediator of cell death (BIM), belongs to BH3-only death activator family. In human chromosome, the gene BCL2L11 is localized on 2q13.
免疫原
Peptide sequence around aa. 67-71 (P-A-S-P-G), according to the protein BCL2L11.
生化/生理作用
Bcl-2-like protein 11 (BCL2L11) is a key factor for determining the cell fate in the absence of cytokines. BCL2L11 is a pro-apoptotic protein, which initiates intrinsic apoptotic pathway and causes apoptosis. BIM initiates apoptosis upon upregulation by tyrosine kinase inhibitors (TKI) and binds to pro-survival Bcl2 family through its SH3 domain. BIM is a key factor to evaluate cancer therapy outcomes. Downregulation of BCL2L11 by either polymorphism or promoter hypermethylation, results in survival of chronic myeloid leukaemia cells and also provides drug resistance. BCL2L11 is associated with lymphomagenesis. Upregulation of MicroRNA (miR-24) suppresses BCL2L11 expression in gastrointestinal tumour, promotes cell proliferation and invasion.
特点和优势
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目标描述
Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD02095895 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~23 kDa |
| species reactivity | human, mouse, rat |
| 浓度 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 western blot: 1:500-1:1000 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (P-A-S-P-G) |
| NCBI登记号 | NP_006529.1 |
| UniProt登记号 | O43521 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... BCL2L11(10018) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
