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Anti-BAMBI antibody produced in rabbit

品牌
Sigma-Aldrich
货号
HPA010819
规格纯度
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody
参考价格
6389.73 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Bone morphogenic protein and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein which is a pseudo receptor belonging to the family of TGF-β (transforming growth factor beta receptor) type I receptors. BAMBI is predominantly expressed in placenta, spleen and kidney medulla and also found liver, prostate, gut and kidney cortex.

免疫原

BMP and activin membrane-bound inhibitor

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

Bone morphogenic protein and activin membrane-bound inhibitor (BAMBI) acts as an inhibitor of TGF-β (transforming growth factor beta receptor) signaling which causes epithelial-mesenchymal transition. Upregulation of BAMBI gene is observed in chronic obstructive pulmonary disease and a number of cancers including thyroid, liver, colorectal cancer and ovarian cancer. BAMBI might regulate the events of inflammation and remodeling processes.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

外形

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

基本信息

人类蛋白质图谱编号HPA010819    Human Protein Atlas characterization data

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
产品线Prestige Antibodies® Powered by Atlas Antibodies
形式buffered aqueous glycerol solution
species reactivityhuman
包装antibody small pack of 25 μL
technique(s)immunofluorescence: 0.25-2 μg/mL
免疫原序列NKRLQDQRQQMLSRLHYSFHGHHSKKGQVAKLDLECMVPVSGHENCCLTCDKMRQADLSNDKILSLVHWGMYSGHGKLEFV
UniProt登记号Q13145
运输wet ice
储存温度−20℃
Gene Informationhuman ... BAMBI(25805)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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