Anti-BAG3 Antibody, clone AC-2

产品说明

一般描述

Bcl2-associated athanogene 3 (BAG3), also known as CAIR-1 or Bis, belongs to a family of six evolutionarily conserved co-chaperone proteins that contain a characteristic C-terminal BAG domain. In most cell types, BAG3 is localized to the cytoplasm, where it regulates the heat shock protein 70 chaperone. BAG3 is activated in response to stressful stimuli, and plays a critical role in modulating multiple cellular processes, including apoptosis, autophagy, embryonic development, and actin rearrangement. Abnormal expression of BAG3 results cardiomyopathy dilated type 1HH.

免疫原

MAP peptide corresponding to human BAG3.

应用

Immunoprecipitation Analysis: A 1:500 dilution from a representative lot detected BAG3 IP′d from 500 µg of HeLa lysate.
Anti-BAG3 Antibody, clone AC-2 detects level of BAG3 & has been published & validated for use in Western Blotting.
Research Category
Apoptosis & Cancer
Research Sub Category
Chaperones

质量

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: A 1:1000 dilution of this antibody detected BAG3 in 10 µg of HeLa cell lysate.

目标描述

~62-80 kDa observed. The calculated molecular weight of this protein is 62 kDa, but can run as high as 80 kDa due to PTM.

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
HeLa cell lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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