Anti-BAFF receptor Antibody

产品说明

一般描述

B-cell-activating factor receptor (BAFF receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) and BLyS receptor 3 (BR3), is a member of the TNF superfamily that regulate immune responses and induce apoptosis. BAFF receptor promotes the survival of mature B-cells and the B-cell response. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase. BAFF receptor is highly expressed in spleen and lymph node, with lower levels found in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. Mutations in BAFF receptor have been associated with immunodeficiency common variable type 4 (CVID4), also called BAFFR defect.

特异性

This antibody recognizes the C-terminus of BAFF receptor.

免疫原

KLH-conjugated linear peptide corresponding to the C-terminus of human BAFF receptor.

应用

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected BAFF receptor in human tonsil tissue.
Detect B-cell-activating factor receptor using this rabbit polyclonal antibody, Anti-BAFF receptor Antibody validated for use in western blotting & IHC.

质量

Evaluated by Western Blotting in human, mouse, and rat spleen tissue lysates.

Western Blotting Analysis: 5 µg/mL of this antibody detected BAFF receptor in 15 µg of human, mouse, and rat spleen tissue lysates.

目标描述

~22 kDa observed. Uniprot describes two isoforms at ~19 kDa Uncharacterized bands may appear in some lysates.

外形

Antigen Affinity Purified

分析说明

Control
Human, mouse, and rat spleen tissue lysates

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息