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Anti-ATAD3A antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1400606
规格纯度
IgG fraction of antiserum, buffered aqueous solution
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

ATAD3A (ATPase family, AAA domain containing 3A) is mapped to human chromosome 1p36.33. The encoded protein is a localized in mitochondrial membrane.

免疫原

ATAD3A (AAH33109.1, 1 a.a. ~ 586 a.a) full-length human protein.

Sequence
MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS

生化/生理作用

ATAD3A (ATPase family, AAA domain containing 3A) was originally considered as a tumor-specific antigen. Mutation in ATAD3A is known to cause a delayed development, optic atrophy, axonal neuropathy, hypotonia and hypertrophic cardiomyopathy. ATAD3A is involved in mitochondrial development, organization of nucleoid, translation of protein, cell growth, and cholesterol metabolism. Downregulation of ATAD3A affects the mitochondrial dynamics, prevents proliferation and changes the interaction between mitochondria and the endoplasmic reticulum. Upregulation of the gene is seen in several cancer types. ATAD3A is known to offer resistance against chemotherapy and radiation. It is responsible for the mitochondrial membrane and import vesicle -mediated transport of AIF (apoptosis inducing factor) from the endoplasmic reticulum into mitochondria. Downregulation of ATAD3A promotes autophagy as well as apoptosis in uterine cervical cancer cells, and also reduces the ability to resist the anticancer drugs. ATAD3A serves as a biomarker for the prognosis of glioblastoma multiforme. It is also found to be involved in cancers such as uterine cervical cancer, lung adenocarcinoma and prostate cancer.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源mouse
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)indirect immunofluorescence: suitable
western blot: 1 μg/mL
UniProt登记号Q9NVI7
运输dry ice
储存温度−20℃
Gene Informationhuman ... ATAD3A(55210)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

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