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ANTI-APCDD1(N-TERMINAL) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1307046
规格纯度
affinity isolated antibody, buffered aqueous solution
参考价格
6098.42 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Adenomatosis polyposis coli down-regulated 1 (APCDD1) encodes a membrane bound glycoprotein. Apcdd1 is predominantly expressed in epidermal and dermal compartments of human hair follicles. In human chromosome, the gene APCDD1 is localized on 18p11.22.

生化/生理作用

Adenomatosis polyposis coli down-regulated 1 (APCDD1) inhibits wnt (wingless/integrated) signalling and promotes human hair growth. Mutations in APCDD1 results in a rare autosomal dominant hereditary hypotrichosis, which is characterized by hair loss due to hair follicle miniaturization. APCDD1 is directly regulated by β-catenin/T-cell factor 4 (TCF4). The high expression of Apcdd1 in colon cancer cells promotes its proliferation. APCDD1 is essential for adipocyte differentiation. Downregulation of APCDD1 in diet induced obesity impairs adipocyte differentiation and causes obesity related metabolic diseases.

外形

Supplied in PBS with 0.09% (W/V) sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 58797 Da
species reactivityhuman
technique(s)immunohistochemistry: 1:10-1:50
western blot: 1:1000
NCBI登记号NP_694545.1
UniProt登记号Q8J025
运输wet ice
储存温度−20℃
Gene Informationhuman ... APCDD1(147495)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

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