位置:首页 > 品牌 > Sigma-Aldrich >

Anti-ADORA2A antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1401009
规格纯度
purified immunoglobulin, buffered aqueous solution
参考价格
4618.16 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Adenosine A2A receptor (ADORA2A) or A2AR is a heptaspanning-membrane-receptor (HSMR) expressed majorly in the basal ganglia especially in the γ-aminobutyric acid (GABA)ergic striatopallidal neurons. The ADORA2A gene is mapped to human chromosome 22q11.23.

免疫原

ADORA2A (NP_000666, 1 a.a. ~ 412 a.a) full-length human protein.

Sequence
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS

生化/生理作用

Mutation in the adenosine A2A receptor (ADORA2A) gene is implicated in the pathophysiology of autism spectrum disorders (ASDs) and panic disorder. A2AR mediates the release of neurotransmitters in γ-aminobutyric acid (GABA)ergic neurons in rats.
ADORA2A activation leads to increased levels of cAMP within the cell. It is known to inhibit the inflammatory action of neutrophil. Abnormal expression of ADORA2A (adenosine A2a receptor) might be involved in the development of glioma. Also, downregulation of the gene might promote the susceptibility towards tumor-associated epilepsy.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)western blot: 1 μg/mL
NCBI登记号NM_000675
UniProt登记号P29274
运输dry ice
储存温度−20℃
Gene Informationhuman ... ADORA2A(135)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号