产品说明
一般描述
ADNP1, also known as Activity-dependent neuroprotector homeobox protein, and encoded by the gene ADNP/ADNP1/KIAA0784, is a potential transcription factor that appears to mediate some of the neuroprotective peptide VIP associated effects involving normal growth and cancer proliferation. ADNP1 is widely expressed and localized to the nucleus. ADNP1 is strongly expressed in heart and skeletal muscle tissue and the brain. ADNP1 is also found expressed in colon and breast cancer tissues but not in normal tissues, thus ADNP1 can be used as a potential cancer marker in some tissues. ADNP1 is upregulated in normal proliferative tissues by VIP, and it may increase the viability of certain cell types through the modulation of p53 activity. Interestingly, new research shows that ADNP1 may be a potential biomarker for Alzheimer’s disease, where ADP1 expression was specifically down-regulated in AD patients.
免疫原
Epitope: Near C-terminus
GST-tagged recombinant protein corresponding to human ADNP1, near the C-terminus.
应用
This Anti-ADNP1 Antibody, clone 5F5.1 is validated for use in Western Blotting for the detection of ADNP1.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
质量
Evaluated by Western Blotting in SH-SY-5Y cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected ADNP1 in 200 µg of SH-SY-5Y cell lysate.
目标描述
~145 kDa observed
外形
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 5F5.1, monoclonal |
| species reactivity | human |
| technique(s) | western blot: suitable |
| 同位素/亚型 | IgG1κ |
| NCBI登记号 | NP_056154 |
| UniProt登记号 | Q9H2P0 |
| 运输 | wet ice |
| Gene Information | human ... ADNP(23394) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
